Tag Archives: lncrna

Long non-coding RNAs (lncRNAs) have been found to perform various functions in a wide variety of important biological processes. To make easier interpretation of lncRNA functionality and conduct deep mining on these transcribed sequences, it is convenient to classify lncRNAs into different groups. Here, researchers from the CAS Key Laboratory of Genome Sciences and Information, China summarize classification methods of ...

Myostatin, a member of the transforming growth factor-β (TGF-β) superfamily of secreted proteins, is a potent negative regulator of myogenesis. Free myostatin induces the phosphorylation of the Smad family of transcription factors, which, in turn, regulates gene expression, via the canonical TGF-β signaling pathway. There is, however, emerging evidence that myostatin can regulate gene expression independent of Smad signaling. As ...

from GenomeWeb NEW YORK (GenomeWeb News) – The National Human Genome Research Institute plans to launch a grant program that would fund efforts to develop innovative computational approaches for interpreting variants found in the non-protein-coding regions of the human genome. NHGRI’s advisory board yesterday approved the program, which will provide up to $500,000 per year to each of five or ...

Cells are highly organized structures. In addition to membrane delimited organelles, proteins and RNAs can organize themselves into specific domains. Some examples include stress granules and subnuclear bodies. This level of organization is essential for the correct execution of multiple processes in the cell, ranging from cell signaling to assembly of structures such as the ribosomes. Here the authors review ...

Job Summary Post-Doc Fellow/Research Associate Job Code: 76_195473 POSTED: Apr 25 Salary: Open Location: Detroit, Michigan Employer: Wayne State University Type: Full-time Organization Type: Higher Education Institution Category: Medical – Clinical Job Description Essential Functions: Assisting with transcriptional and post-transcriptional control of cell signaling in the immune system under physiological and pathological situations. Working with both human derived cells and ...

We have created a custom lncRNA expression array design (gencode.v15.lncrna.2probe.version1) with probes targeting the Gencode v15 human lncRNA annotation. The design file is for the standard Agilent 8x60k expression array format, with two 60mer probes targeting each of 22,001 lncRNA transcripts. The array also contains 17,535 catalogue probes targeting protein-coding genes. Similar arrays designed against an earlier version of Gencode ...

While the role of small non-coding RNAs, such as miRNAs, in apoptosis control is well established, long non-coding RNAs (lncRNAs) have received less attention. Growth Arrest-Specific 5 (GAS5) encodes multiple snoRNAs within its introns, whilst exonic sequences produce lncRNA which can act as a riborepressor of the glucocorticoid and related receptors. GAS5 negatively regulates the survival of lymphoid and breast ...

The tumor microenvironment is a crucial determinant in tumor progression. Interstitial extracellular matrix (ECM), such as type I collagen (Col-1), is aberrantly enriched in the tumor microenvironment and promotes tumor progression. Long intergenic non-coding RNAs (lincRNA) are a new family of regulatory RNAs that modulate fundamental cellular processes via diverse mechanisms. Researchers at Tulane University School of Medicine investigated whether ...

The incidence of lung diseases and cancer caused by cigarette smoke is increasing. The molecular mechanism(s) of gene regulation induced by cigarette smoke that ultimately lead to cancer remains unclear. This report describes a novel long non-coding RNA (LncRNA) that is induced by cigarette smoke extract (CSE) both in vitro and in vivo and is elevated in numerous lung cancer ...