Tag Archives: non-coding rna

Present Scenario of Long Non-Coding RNAs in Plants

lncRNA

Small non-coding RNAs have been extensively studied in plants over the last decade. In contrast, genome-wide identification of plant long non-coding RNAs (lncRNAs) has recently gained momentum. LncRNAs are now being recognized as important players in gene regulation, and their potent regulatory roles are being studied comprehensively in eukaryotes. LncRNAs were first reported in humans in 1992. Since then, research ...

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Perspectives of long non-coding RNAs in cancer

lncRNA

A recent advance in transcriptomics has spawned the ‘Decade of non-coding RNAs’ by potentiating the growing numbers of long non-coding RNA in cancer. LncRNA involvement in cancer denotes its significance beyond our perception as they participate in tumor suppression and promoting oncogenesis, which raises them as a mighty class of effectors or regulators. Aberrantly expressed lncRNAs interact with major protein ...

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Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function

lncRNA

The angiogenic function of endothelial cells is regulated by numerous mechanisms but the impact of long noncoding RNAs (lncRNAs) has hardly been studied. Goethe-University researchers set out to identify novel and functionally important endothelial lncRNAs. Epigenetically controlled lncRNAs in human umbilical vein endothelial cells (HUVEC) were searched by exon-array analysis after knockdown of the histone demethylase JARID1B. Molecular mechanisms were ...

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Non-Coding RNAs – New Players in Skin Wound Healing

lncRNA

Significance: Wound healing is a basic physiological process that is utilized to keep the integrity of the skin. Impaired wound repair, such as chronic wounds and pathological scars, presents a major health and economic burden worldwide. To date, efficient targeted treatment for these wound disorders is still lacking, which is largely due to our limited understanding of the biological mechanisms ...

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The short ASCC3 RNA isoform functions as a long non-coding RNA

Researchers from the Francis Crick Institute analyzed the transcription-related DNA damage response on a genome-wide scale with great spatial and temporal resolution. Upon UV irradiation, a slowdown of transcript elongation and restriction of gene activity to the promoter-proximal ∼25 kb is observed. This is associated with a shift from expression of long mRNAs to shorter isoforms, incorporating alternative last exons ...

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Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability

Cells communicate with one another to create microenvironments and share resources. One avenue by which cells communicate is through the action of exosomes. Exosomes are extracellular vesicles that are released by one cell and taken up by neighbouring cells. But how exosomes instigate communication between cells has remained largely unknown. Researchers from the University of New South Wales present evidence ...

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Call for papers – non-coding RNA methods

lncRNA

The journal Non-Coding RNA is now accepting submissions for a special issue on Non Coding RNA methods. The special issue co guest-edited by Dr. Piero Carninci from the RIKEN Center for Life Science Technologies in Japan and Dr. Florent Hubé from the National Center for Scientific Research (CNRS) in Paris. This special issue will group together manuscripts that report on ...

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Non-coding RNA in infection – 18–24 September 2016 – Würzburg, Germany

lncRNA

Infections are an intricate interplay between hosts and pathogens involving dynamic changes in gene expression. This does not only involve changes in the expression of protein coding genes but also of large diverse groups of non-coding RNAs in the host and pathogens. However, in the vast majority of cases the biological roles and mechanisms of action of non-coding RNAs remain ...

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Developmentally regulated long non-coding RNAs in Xenopus tropicalis

lncRNA

Advances in RNA sequencing technologies have led to the surprising discovery that a vast number of transcripts emanate from regions of the genome that are not part of coding genes. Although some of the smaller ncRNAs such as microRNAs have well-characterized functions, the majority of long ncRNA (lncRNA) functions remain poorly understood. Understanding the significance of lncRNAs is an important ...

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Call For Papers – Special Issue: Non-coding RNAs in Cancer

Editor: Aamir Ahmad, PhD, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA Deadline: October 15th, 2016 Cancer is a deadly disease that affects millions of lives worldwide. The fight against cancer relies heavily on the availability of robust biomarkers for diagnosis, therapy and prognosis. In recent years, non-coding RNAs have attracted a lot of attention for their role in human cancers. The ...

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