An updated LncTarD 2.0 database provides a comprehensive resource on key lncRNA-target regulations, their influenced functions and lncRNA-mediated regulatory mechanisms in human diseases. LncTarD 2.0 was updated with several new features, including (i) an increased number of disease-associated lncRNA entries, where the current release provides 8360 key lncRNA-target regulations, with 419 disease subtypes and 1355 lncRNAs; (ii) predicted 3312 out ...
Read More »Diabetes-causing gene can be regulated like a rheostat
Researchers at the Centre for Genomic Regulation (CRG) and Imperial College London have found a switch that regulates the activity of a gene that causes diabetes. The findings highlight potential...
Read More »New findings may contribute to better diagnosis and treatment of liver cancer
In a new study, researchers at Karolinska Institutet have identified the presence of a specific connection between a protein and an lncRNA molecule in liver...
Read More »lncRNA identified as potential new diagnostic and therapeutic target for lung cancer
Scientists recently reported the key role of histone acetylation-regulated long noncoding RNA termed as lysosome cell death regulator (LCDR) in tumor survival, providing a potential diagnostic and therapeutic target for lung cancer.Led by Prof. GAO Shan...
Read More »RNA molecules with no apparent function represent a new therapeutic approach against fungal infection by Candida
Fungi of the Candida genus cause diseases such as vaginal candidiasis (highly prevalent but not serious) and systemic candidiasis (rare but can be fatal in immunocompromised patients). Although some...
Read More »RNAging: An exercise-regulated long noncoding RNA counteracts muscle aging
Skeletal muscle displays remarkable plasticity upon exercise, but is at the same time one of our organs that is most affected by aging. Skeletal muscle aging is characterized by estimated yearly losses of ~1% muscle mass and ~3% muscle strength in the elderly...
Read More »Machine learning analysis of long non-coding RNAs reveals new prognostic cancer biomarkers
Catalogue of 166 biomarkers generated through machine learning analysis of long non-coding RNAs A new batch of prognostic cancer biomarkers have...
Read More »New strategy against treatment-resistant prostate cancer identified
A study from Washington University School of Medicine in St. Louis has identified an long non-coding RNA molecule that suppresses prostate tumors...
Read More »Novel lncRNA, Caren, counteracts heart failure progression
is abundantly expressed in cardiomyocytes. They showed that it enhances energy production by...
Read More »Implication of repeat insertion domains in the trans-activity of the long non-coding RNA ANRIL
Long non-coding RNAs have emerged as critical regulators of cell homeostasis by modulating gene expression at chromatin level for instance...
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