Methods

LncFinder – an integrated platform for long non-coding RNA identification

lncRNA

Discovering new long non-coding RNAs (lncRNAs) has been a fundamental step in lncRNA-related research. Nowadays, many machine learning-based tools have been developed for lncRNA identification. However, many methods predict lncRNAs using sequence-derived features alone, which tend to display unstable performances on different species. Moreover, the majority of tools cannot be re-trained or tailored by users and neither can the features ...

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LncPipe – A Nextflow-based pipeline for identification and analysis of long non-coding RNAs from RNA-Seq data

lncRNA

Recently, long noncoding RNA molecules (lncRNA) captured widespread attentions for its critical roles in diverse biological process and important implications in variety of human diseases and cancers. Identification and profiling of lncRNAs is a fundamental step to advance our knowledge on their function and regulatory mechanisms. However, RNA sequencing based lncRNA discovery is limited due to complicated operations and implementation. ...

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HLPI-Ensemble – Prediction of human lncRNA-protein interactions based on ensemble strategy

lncRNA

LncRNA plays an important role in many biological and disease progression by binding to related proteins. However, the experimental methods for studying lncRNA-protein interactions are time-consuming and expensive. Although there are a few models designed to predict the interactions of ncRNA-protein, they all have some common drawbacks that limit their predictive performance. Researchers from Liaoning University present a model called HLPI-Ensemble designed ...

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