Tag Archives: miRNA

A long noncoding RNA-associated competing endogenous RNA network in periodontitis

lncrna

Long noncoding RNAs (lncRNAs) play critical and complex roles in regulating various biological processes of periodontitis. This bioinformatic study aims to construct a putative competing endogenous RNA (ceRNA) network by integrating lncRNA, miRNA and mRNA expression, based on high-throughput RNA sequencing and microarray data about periodontitis. University of Leipzig researchers constructed a lncRNA-associated ceRNA network from miRNA and mRNA expression ...

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The Influence of microRNAs and Long Non-Coding RNAs in Cancer Chemoresistance

lncRNA

Innate and acquired chemoresistance exhibited by most tumours exposed to conventional chemotherapeutic agents account for the majority of relapse cases in cancer patients. Such chemoresistance phenotypes are of a multi-factorial nature from multiple key molecular players. The discovery of the RNA interference pathway in 1998 and the widespread gene regulatory influences exerted by microRNAs (miRNAs) and other non-coding RNAs have ...

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In Silico Characterization of miRNA and Long Non-Coding RNA Interplay in Multiple Myeloma

lncRNA

The identification of deregulated microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in multiple myeloma (MM) has progressively added a further level of complexity to MM biology. In addition, the cross-regulation between lncRNAs and miRNAs has begun to emerge, and theoretical and experimental studies have demonstrated the competing endogenous RNA (ceRNA) activity of lncRNAs as natural miRNA decoys in pathophysiological conditions, ...

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LncRNAs and miRNAs – potential biomarkers and therapeutic targets for prostate cancer

Prostate cancer (PCa) is the second lethal disease for men in western countries. Although androgen receptor (AR) signaling has been widely investigated, noncoding RNAs (ncRNAs), deficient of open reading frame, have also received considerable attention. Growing studies showed that the aberrant ncRNAs expression contributed to cell proliferation, metastasis and drug resistance in PCa. Therefore, therapeutically targeting ncRNAs may synergize androgen ...

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An artificial lncRNA targeting multiple miRNAs overcomes sorafenib resistance in hepatocellular carcinoma cells

lncRNA

Sorafenib resistance remains a major obstacle for the effective treatment of hepatocellular carcinoma (HCC), and a number of miRNAs contribute to this resistance. However, the regulatory networks of miRNAs are very complex, thus inhibiting a single miRNA may sequentially activate other compensatory pathways. In the present study, researchers at Harbin Medical University generated an artificial long non-coding RNA (AlncRNA), which simultaneously ...

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A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA

Highlights Identification of LncND with a Catarrhine insertion of 16 MREs for miR-143-3p LncND regulates expression of Notch genes by sequestering miR-143-3p High expression of LncND in radial glia cells in human VZ and OSVZ LncND appears to be involved in the expansion of radial glia cells in primates Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved category ...

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RNA regulatory networks in animals and plants: a long noncoding RNA perspective

A recent highlight of genomics research has been the discovery of many families of transcripts which have function but do not code for proteins. An important group is long noncoding RNAs (lncRNAs), which are typically longer than 200 nt, and whose members originate from thousands of loci across genomes. The authors review progress in understanding the biogenesis and regulatory mechanisms ...

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