Tag Archives: gene regulation

Scientists have identified a non-coding RNA, called Paupar, influences how healthy brains develop during early life. They have shown that Paupar orchestrates proteins that control neurodevelopment...

Pancreatic ductal adenocarcinoma (PDA) is a highly metastatic disease with limited therapeutic options. Genome and transcriptome analyses have identified signalling pathways and cancer driver genes with implications in patient stratification and targeted therapy. However, these analyses were performed in bulk samples and focused on coding genes, which represent a small fraction of the genome. Researchers at the Columbia University Medical Center developed ...

A significant proportion of mammalian genomes corresponds to genes that transcribe long non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning the roles played...

Long noncoding RNA (lncRNA) molecules are some of the newest and least understood players in gene regulation. Hence, we need good model systems with well-defined RNA and protein components. One such system is paraspeckles – protein-rich...

David Geffen School Of Medicine – Medicine-Gastroenterology Recruitment Period – Open August 17th, 2017 through November 17th, 2017 Description The Padua lab has a keen interest in understanding gene regulation and signaling pathways in the context of complex biological phenomena. Our clinical interests are in inflammatory bowel disease (IBD) and colon cancer diagnosis. One focus of the lab will be ...

Position Title: Postdoctoral Research Associate_Calabrese Lab Vacancy ID: PDS001253 Department: Pharmacology – 424001 Position Type: Postdoctoral Scholar Full-time/Part-time: Full Time FTE: 1.0 Estimated Duration of Appointment: 12 Months Work Location: Chapel Hill, NC Position Summary The Calabrese laboratory is seeking a postdoctoral fellow to study molecular mechanisms of gene regulation induced by long noncoding RNAs (lncRNAs). Project Details Over 70% ...

A combination of transcription factors, enhancers, and epigenetic marks determines the expression of the key transcription factor FoxP3 in regulatory T cells (Tregs). Adding an additional layer of complexity, the long noncoding RNA (lncRNA) Flicr (Foxp3 long intergenic noncoding RNA) is a negative regulator that tunes Foxp3 expression, resulting in a subset of Tregs with twofold- to fivefold-lower levels of ...

Position Title: Postdoctoral Research Associate_Calabrese Lab Vacancy ID: PDS001253 Department: Pharmacology – 424001 Position Type: Postdoctoral Scholar Full-time/Part-time: Full Time FTE: 1.0 Estimated Duration of Appointment: 12 Months Posting Open Date: 03/02/2016 Open Until Filled: Yes Work Location: Chapel Hill, NC Position Summary The Calabrese laboratory is seeking a postdoctoral fellow to study molecular mechanisms of gene regulation induced by ...

Emerging evidence indicates that long noncoding RNAs (lncRNAs) are actively involved in a number of developmental and tumorigenic processes. Here, Northwestern University researchers describe the first successful use of spherical nucleic acids as an effective nanoparticle platform for regulating lncRNAs in cells; specifically, for the targeted knockdown of the nuclear-retained metastasis associated lung adenocarcinoma transcript 1 (Malat1), a key oncogenic ...

Genome-wide association studies in livestock based on high-resolution genotyping and sequencing have revealed that the majority of signals associated with complex phenotypic traits are located outside of annotated protein-coding regions in the genome. The approaches of next-generation sequencing applied to whole transcriptome and chromatin profiles have provided information about existing genome-wide transcriptional activity and have revealed that the genomes are ...