Tag Archives: HOTAIR

An inexpensive, simple and rapid sensor platform capable of detecting cancer-related long non-coding RNA (lncRNA) with high accuracy is of great interest in the field of molecular diagnostics. Researchers...

Glioblastoma multiforme (GBM) is the most common and aggressive malignant adult primary brain tumor. Despite surgical resection followed by radiotherapy and chemotherapy, the median survival rate is...

LncRNA HOX transcript antisense RNA (HOTAIR) is involved in lots of cancers. The pro-survival protein Bcl-w is frequently found in cancer development...

The Institute for Computational Genomics, RWTH Aachen University performs cutting edge research on computational and genomic methods for understanding regulatory and epigenetic processes driving cell differentiation and diseases. We are particularly interested in studying RNA-DNA interactions as mechanisms of transcriptional control. For example, we have recently shown how the long-noncoding RNA HOTAIR interacts with DNA via triple helices to control ...

University of Texas at Arlington researchers have established a link between hypoxia, a condition that reduces the flow of oxygen to tissues, and HOTAIR, a noncoding RNA or molecule that has been implicated in several types of cancer. RNA, or ribonucleic acid, is present in all living cells. Its primary role is to carry instructions from DNA. In a study ...

Long noncoding RNA (LncRNA) homeotic genes (HOX) transcript antisense RNA (HOTAIR) has been reported to play a vital role in various cancers. It has been found that HOTAIR was upregulated in non-small cell lung cancer (NSCLC) and involved in cell invasion and metastasis. The aberrant expression of HOTAIR is expected to serve as a potential biomarker for patients with NSCLC. ...

The discovery of thousands of long noncoding RNAs (lncRNAs) in mammals raises a question about their functionality. It has been shown that some of them function post-transcriptionally via formation of inter-molecular duplexes. Sequence alignment tools are frequently used for transcriptome-wide prediction of RNA-RNA interactions. However, such approaches have poor prediction accuracy since they ignore RNA secondary structure and interaction energy. ...

Long non-coding RNAs (lncRNAs) are gradually drawing the attention of the cancer research community due to their pivotal involvement in tumorigenesis and tumor progression. These non-protein coding, >200 nucleotides long transcripts are aberrantly expressed in the majority of human malignancies, including gastric cancer (GC). The discovery that lncRNAs are severely deregulated across different human malignancies has prompted the pursuit of ...

There is a growing perception that long non-coding RNAs (lncRNAs) modulate cellular function. In this study, researchers from RWTH University Medical School analyzed the role of the lncRNA HOTAIR in mesenchymal stem cells (MSCs) with particular focus on senescence-associated changes in gene expression and DNA-methylation (DNAm). HOTAIR binding sites were enriched at genomic regions that become hypermethylated with increasing cell culture ...

In the complex network of nuclear hormone receptors, the long non-coding RNAs (lncRNAs) are emerging as critical determinants of hormone action. Here researchers from the Institute of Cell Biology and Neurobiology, Rome investigated the involvement of selected cancer-associated lncRNAs in Estrogen Receptor (ER) signaling. Prior studies by Chromatin Immunoprecipitation (ChIP) Sequencing showed that in prostate cancer cells ERs form a ...