Tag Archives: lncrna

Rare splice variants in long non-coding RNAs

lncrna

Long non-coding RNAs (lncRNAs) form a substantial component of the transcriptome and are involved in a wide variety of regulatory mechanisms. Compared to protein-coding genes, they are often expressed at low levels and are restricted to a narrow range of cell types or developmental stages. As a consequence, the diversity of their isoforms is still far from being recorded and ...

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The decade of exosomal long RNA species

lncRNA

Exosomes have emerged as a novel approach for the treatment and diagnosis of cancer after RNA content was discovered in exosomes in 2007. As important meditators of intercellular communication, exosomes have become a strong focus of investigation for researchers in the past decade, as witnessed through the exponential increase of research on exosomes. The capability of exosomes to transfer functionally ...

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The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells

lncRNA

Tumor cells display features that are not found in healthy cells. How they become immortal and how their specific features can be exploited to combat tumorigenesis are key questions in tumor biology. Here researchers from the IMBA Vienna describe the long non-coding RNA cherub that is critically required for the development of brain tumors in Drosophila but is dispensable for ...

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Termination of nuclear lncRNA transcription promotes mitochondrial genome maintenance

lncrna

Most DNA in the genomes of higher organisms does not code for proteins. RNA Polymerase II (Pol II) transcribes non-coding DNA into long non-coding RNAs (lncRNAs), but biological roles of lncRNA are unclear. Researchers at the University of Copenhagen found that mutations in the yeast lncRNA CUT60 result in poor growth. Defective termination of CUT60 transcription causes read-through transcription across the ...

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A long noncoding RNA-associated competing endogenous RNA network in periodontitis

lncrna

Long noncoding RNAs (lncRNAs) play critical and complex roles in regulating various biological processes of periodontitis. This bioinformatic study aims to construct a putative competing endogenous RNA (ceRNA) network by integrating lncRNA, miRNA and mRNA expression, based on high-throughput RNA sequencing and microarray data about periodontitis. University of Leipzig researchers constructed a lncRNA-associated ceRNA network from miRNA and mRNA expression ...

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An epigenomic approach to identifying differential overlapping and cis-acting lncRNAs

lncrna

Long noncoding RNAs (lncRNAs) are critical regulators of cell biology whose alteration can lead to the development of diseases such as cancer. The potential role of lncRNAs and their epigenetic regulation in response to platinum treatment are largely unknown. Researchers at La Paz University Hospital analyzed four paired cisplatin-sensitive/resistant non-small cell lung cancer and ovarian cancer cell lines. The epigenetic landscape ...

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