Tag Archives: biomarker

Long Noncoding RNA in Cancer

lncrna

Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the human genome, may hold missing drivers of cancer and have gained attention recently as a potentially crucial...

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Clinical roles of the aberrantly expressed lncRNAs in lung squamous cell carcinoma

lncRNA

Lung squamous cell carcinoma (LUSC) accounts for a significant proportion of lung cancer and there have been few therapeutic alternatives for recurrent LUSC due to the lack of specific driver molecules. To investigate the prospective role of lncRNAs in the tumorigenesis and progression of LUSC, researchers at Guangxi Medical University calculated aberrantly expressed lncRNAs based on The Cancer Genome Atlas ...

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Plasma lncRNA HOTAIR could serve as a promising biomarker for diagnosing and monitoring NSCLC

lncrna

Long noncoding RNA (LncRNA) homeotic genes (HOX) transcript antisense RNA (HOTAIR) has been reported to play a vital role in various cancers. It has been found that HOTAIR was upregulated in non-small cell lung cancer (NSCLC) and involved in cell invasion and metastasis. The aberrant expression of HOTAIR is expected to serve as a potential biomarker for patients with NSCLC. ...

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Long noncoding RNA expression profile in acute myeloid leukemia identifies a distinct signature and a new biomarker

lncRNA

Long noncoding RNAs are defined as transcripts larger than 200 nucleotides but without protein-coding potential. Cumulative evidence points towards an important role of long noncoding RNAs in cancer initiation, development and progression. In this study researchers from the Cancer Research Center of Toulouse sought to evaluate the long noncoding RNA expression profile of patients with cytogenetically normal acute myeloid leukemia. ...

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lncRNA SNHG6 is a Potential Biomarker for Hepatocellular Carcinoma

lncRNA

Long Non-coding RNAs (lncRNAs) refer to all non-protein coding transcripts longer than 200 nucleotides. Their critical roles in different biological pathways have been already well established. Altered expression of lncRNAs can be involved in the cancer initiation and/or progression. Since patients with hepatocellular carcinoma (HCC) are usually diagnosed in late stages, developing diagnostic methods seems to be essential. In this ...

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Novel lincRNA SLINKY is a prognostic biomarker in kidney cancer

lncRNA

Clear cell renal cell carcinomas (ccRCC) show a broad range of clinical behavior, and prognostic biomarkers are needed to stratify patients for appropriate management. Stanford University researchers  sought to determine whether long intergenic non-coding RNAs (lincRNAs) might predict patient survival. Candidate prognostic lincRNAs were identified by mining The Cancer Genome Atlas (TCGA) transcriptome (RNA-seq) data on 466 ccRCC cases (randomized ...

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