Tag Archives: lung cancer

lncRNA-based therapy cures lung cancer in mouse models

lncrna

By turning down the activity of a specific RNA molecule, researchers at Sahlgrenska Academy, Sweden, have cured lung tumors in mice by 40-50 percent. The results, published in Nature Communications, represent the tip of the iceberg in an extensive research project in which 633 new biomarkers for 14 types of cancer have been identified. A research group led by Chandrasekhar Kanduri, professor ...

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An epigenomic approach to identifying differential overlapping and cis-acting lncRNAs

lncrna

Long noncoding RNAs (lncRNAs) are critical regulators of cell biology whose alteration can lead to the development of diseases such as cancer. The potential role of lncRNAs and their epigenetic regulation in response to platinum treatment are largely unknown. Researchers at La Paz University Hospital analyzed four paired cisplatin-sensitive/resistant non-small cell lung cancer and ovarian cancer cell lines. The epigenetic landscape ...

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Intersecting transcriptomic profiling technologies and long non-coding RNA function in lung adenocarcinoma

lncrna

Previously thought of as junk transcripts and pseudogene remnants, long non-coding RNAs (lncRNAs) have come into their own over the last decade as an essential component of cellular activity, regulating a plethora of functions within multicellular organisms. lncRNAs are now known to participate in development, cellular homeostasis, immunological processes, and the development of disease. With the advent of next generation ...

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lncRNAs LOC146880 and ENST00000439577 may promote the progression of NSCLC

lncRNA

To identify what long non-coding RNAs (lncRNAs) are involved in non-small cell lung cancer (NSCLC), researchers from the Shanghai Jiao Tong University School of Medicine analyzed microarray data on gene expression and methylation. Gene expression chip and HumanMethylation450BeadChip were used to interrogate genome-wide expression and methylation in tumor samples. Differential expression and methylation were analyzed through comparing tumors with adjacent ...

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Lung Cancer Research Foundation Awards Grant to lncRNA Researcher

lncRNA

The Lung Cancer Research Foundation (LCRF™) announced the awardees of its 2016 Scientific Grant Program at the Eleventh Annual Lung Cancer Awareness Luncheon, held on Monday, October 17, at The Pierre in New York City. In another record-breaking year, LCRF awarded $2.2 million in research grants to 15 researchers as part of the LCRF Scientific Grant Program, an annual program ...

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Meta analysis of GWAS datasets reveals lung cancer risk lncRNA variant

lncRNA

Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. Duke University School of Medicine researchers performed a large-scale meta-analysis of 690,564 SNPs in 15,531 autosomal lncRNAs by using datasets from six previously published genome-wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium ...

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Long noncoding and circular RNAs in lung cancer

lncRNA

Better understanding and management of lung cancer are needed. Although much has been learned from known protein coding genes, long noncoding RNAs (lncRNAs), a relatively new and fast evolving large family of transcripts, have recently generated much attention for new discoveries. LncRNAs play critical regulatory functions and are emerging as new players in tumorigenesis and phenotypic determinators of lung cancer. ...

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Functional annotation of noncoding variants and prioritization of cancer-associated lncRNAs in lung cancer

lncRNA

Multiple computational tools have been widely applied to the detection of coding driver mutations in cancer; however, the prioritization of pathogenic non-coding variants remains a difficult and demanding task. The present study was performed to distinguish non-coding disease-causing mutations from neutral ones, and to prioritize potential cancer-associated long non-coding RNAs (lncRNAs) with a logistic regression model in lung cancer. A ...

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The Emerging Role and Promise of Long Noncoding RNAs in Lung Cancer Treatment

lncRNA

Lung cancer is the leading cause of cancer death around the world. The advanced discovery of numerous long noncoding RNAs (lncRNAs) has dramatically changed the understanding of biology of human cancers, including lung cancer. LncRNAs are a group of noncoding RNAs (ncRNAs) with a length greater than 200 nucleotides with limited or no protein-coding capacity. Increasing evidence has shown that ...

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Long noncoding RNAs in lung cancer – what we know in 2015

lncRNA

Lung cancer ranks as the first most common cancer and the first leading cause of cancer-related death in China and worldwide. Due to the difficulty in early diagnosis and the onset of cancer metastasis, the 5-year survival rate of lung cancer remains extremely low. Long noncoding RNAs (lncRNAs), which lacking protein-coding ability, have recently emerged as pivotal participants in biological ...

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