from Biocompare by Jeffrey M. Perkel There’s an old saying that you can judge a man by the company he keeps. The same can be said of biomolecules. If you want to know what a protein is doing, you can get a hint from the functions of its interaction partners. These days, there is considerable research interest in the class ...
Read More »RNAi Screens and the Reagents That Enable Them
from Genetic Engineering News 2013 (Vol. 33, No. 19) by Jeanene Swanson RNAi screens for functional genomics typically look for loss- or gain-of-function phenotypes. They currently have many applications, including target discovery and validation, lead identification and optimization, mechanism of action discovery, predictive toxicology, and biomarker identification. While reagents are gaining ground, technical difficulties remain in how best to perform ...
Read More »Molecular Biology of Long Non-coding RNAs
Khalil, Ahmad M.; Coller, Jeff (Eds.) 2014, VI, 166 p. 18 illus., 16 illus. in color. ISBN 978-1-4614-8620-6 About this book Brings together key experts in the field of lncRNAs Has appeal for basic scientists and clinicians Focuses on the recently discovered, and less understood, class of long non-coding RNAs Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm ...
Read More »What are lncRNAs?
from Exiqon.com It was traditionally thought that the transcriptome would be mostly comprised of mRNAs, however advances in high-throughput RNA sequencing technologies have revealed the complexity of our genome. Non-coding RNA is now known to make up the majority of transcribed RNAs and in addition to those that carry out well-known housekeeping functions (e.g. tRNA, rRNA etc), many different types ...
Read More »LncRNA Expression Microarray Platform: Gencode v15
We have created a custom lncRNA expression array design (gencode.v15.lncrna.2probe.version1) with probes targeting the Gencode v15 human lncRNA annotation. The design file is for the standard Agilent 8x60k expression array format, with two 60mer probes targeting each of 22,001 lncRNA transcripts. The array also contains 17,535 catalogue probes targeting protein-coding genes. Similar arrays designed against an earlier version of Gencode ...
Read More »Featured New Product – The SmartChip Human LncRNA1 Panel
The field of lncRNA research is in the midst of a rapid discovery phase, but that doesn’t mean your reagents have to be“experimental”. In collaboration with Biogazelle, we’ve designed SmartChip Human lncRNA-1 Panels to maximize your investigation of lncRNA expression. They contain over 1700 triplicate, predispensed PCR assays that have been extensively validated and annotated. In addition, we’ve ensured that ...
Read More »Arraystar Inc announces the launch of their version 3.0 lncRNA microarray
Arraystar Inc., the industry leader in Long non-coding RNA (LncRNA) analysis, is excited to announce the launch of our version 3.0 LncRNA microarray. LncRNAs are similar to messenger RNAs, yet do not encode proteins. These intriguing transcripts have recently captured the imagination of scientists investigating the regulation and biomarker profiling of animal development and diseases, such as cancer and Alzheimer’s. ...
Read More »Featured Product – Knockdown and detection of lncRNA
Thermo Scientific Lincode siRNA and Solaris lncRNA Expression Assays Comprehensive pre-designed reagents for investigation of human lncRNAs siRNAs with enhanced specificity from the RNAi leaders High-efficiency qPCR assays for specific and dependable lncRNA detection Lincode siRNAs have been created to support the growing interest in analysis of long noncoding RNAs (lncRNA). As with siGENOME and ON-TARGETplus siRNAs, which target protein-coding ...
Read More »Exiqon launches LNA™ gapmers for inhibition of mRNA and lncRNA in functional studies
from Global Newswire Exiqon A/S (NASDAQ OMX: EXQ), a leading supplier of high-value gene expression analysis products, today announced the launch of its LNA™ longRNA GapmeR products for specific and efficient inhibition of mRNA and lncRNA. The LNA™ longRNA GapmeRs are high affinity antisense oligonucleotides used for functional analysis, allowing researches to study the gene function and downstream biological consequences ...
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