Tag Archives: tumorigenesis

Colorectal cancer (CRC) is one of the most common malignancies in the world. Easier recurrence and metastasis is the main cause of mortality in CRC...

Tumor cells display features that are not found in healthy cells. How they become immortal and how their specific features can be exploited to combat tumorigenesis are key questions in tumor biology. Here researchers from the IMBA Vienna describe the long non-coding RNA cherub that is critically required for the development of brain tumors in Drosophila but is dispensable for ...

In this study, researchers from Harbin Medical University performed RNA-Seq of 33 breast specimens, and the expression of linc00152 was...

Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third leading cause of cancer-related death. Critical roles for long non-coding RNAs (lncRNAs) have recently been demonstrated for a variety of cancers, including hepatocellular carcinoma. However, the effect and mechanism of lncRNAs in HCC tumorigenesis and chemoresistance have not been extensively characterized. In the current study, ...

Lung squamous cell carcinoma (LUSC) accounts for a significant proportion of lung cancer and there have been few therapeutic alternatives for recurrent LUSC due to the lack of specific driver molecules. To investigate the prospective role of lncRNAs in the tumorigenesis and progression of LUSC, researchers at Guangxi Medical University calculated aberrantly expressed lncRNAs based on The Cancer Genome Atlas ...

LNCRNAS IN TUMORIGENESIS National Institute of Environmental Health Sciences, Research Triangle Park, NC Position Description: A postdoctoral position is available in the Signal Transduction Laboratory at the National Institute of Environmental Health Sciences (NIEHS), a major research institute of the NIH located in the research triangle park of North Carolina, in the group of Dr. Xiaoling Li. NIEHS offers an ...

Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, Indiana University researchers analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 healthy controls and constructed a functional lncRNA-mRNA co-expression network. They revealed two distinctive co-expression patterns associated with breast cancer, reflecting different underlying regulatory mechanisms: (1) ...

Breast cancer is the most commonly diagnosed cancer in women and is the second leading cause of cancer death among women. Hundreds of thousands of women worldwide lose their battle against this cancer each year, and it is estimated that one in eight US women will develop invasive breast cancer in her lifetime. The heterogeneity of breast cancer, with its ...

Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, Indiana University researchers analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 healthy controls and constructed a functional lncRNA-mRNA co-expression network. They revealed two distinctive co-expression patterns associated with breast cancer, reflecting different underlying regulatory mechanisms: (1) ...

Although long non-coding RNAs (lncRNAs) predominately reside in the nucleus and exert their functions in many biological processes, their potential involvement in cytoplasmic signal transduction remains unexplored. Now, researchers from MD Anderson Cancer Center have identified a cytoplasmic lncRNA, LINK-A (long intergenic non-coding RNA for kinase activation), which mediates HB-EGF-triggered, EGFR:GPNMB heterodimer-dependent HIF1α phosphorylation at Tyr 565 and Ser 797 by ...