Tag Archives: colorectal cancer

Identification of key lncRNAs in colorectal cancer progression based on associated protein–protein interaction analysis

lncRNA

Colorectal cancer (CRC) was one of the most commonly diagnosed malignancies. The molecular mechanisms involved in the progression of CRC remain unclear. Accumulating evidences showed that long noncoding RNAs (lncRNAs) played key roles in tumorigenesis, cancer progression, and metastasis. Researchers at Fudan University aimed to explore the roles of lncRNAs in the progression of CRC. In this study, the researchers aimed to ...

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The novel long intergenic noncoding RNA UCC promotes colorectal cancer

lncRNA

The human genome contains thousands of long intergenic noncoding RNAs (lincRNAs). However, the functional roles of these transcripts and the mechanisms responsible for their deregulation in colorectal cancer (CRC) remain elusive. Researchers at Sun Yat-sen University found a novel lincRNA termed upregulated in CRC (UCC) was highly expressed in human CRC tissues and cell lines. UCC levels correlated with lymph node ...

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Silencing of long non-coding RNA SBDSP1 suppresses tumor growth and invasion

lncRNA

Long non-coding RNAs (lncRNAs) play critical roles in tumor development and progression. This study was undertaken to examine the expression and biological functions of a novel lncRNA SBDSP1 in colorectal cancer (CRC). Researchers from the Fudan University Shanghai Cancer Center used Quantitative real-time PCR analysis to measure the expression of SBDSP1 in CRC tissues and cell lines. Knockdown of SBDSP1 ...

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Exosomal long noncoding RNA CRNDE-h as a novel serum-based biomarker for diagnosis and prognosis of colorectal cancer

Cancer-secreted long non-coding RNAs (lncRNAs) are emerging mediators of cancer-host cross talk. Researchers at Shandong University aimed to illustrate the clinical significance of the lncRNA CRNDE-h in exosomes purified from the serum of patients with colorectal cancer (CRC). The study was divided into four parts: The exosome isolated methods and lncRNA detected methods which accurately and reproducibly measure CRC-related exosomal ...

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Comprehensive analysis of epigenetic pattern of long noncoding RNA loci in colorectal cancer

lncRNA

Colorectal cancer (CRC) is one of the most common and severe cancers worldwide. The occurrence of CRC is developed by accumulation of genetic and epigenetic alteration in colon cells. Work over the last decade has proposed that epigenetic changes such as DNA methylation, histone modification of protein coding genes play an important role in CRC development. However, the epigenetic pattern ...

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The high expression of long non-coding RNA PANDAR indicates a poor prognosis for colorectal cancer

lncRNA

Long non-coding RNAs (lncRNAs) have been shown to have crucial regulatory roles in human cancer biology. LncRNA PANDAR is a novel identified lncRNA that was previously reported to be increased in various cancers; however, its effect in colorectal cancer (CRC) remains unknown. The aim of this study was to explore the expression and role of lncRNA PANDAR in CRC. The ...

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Long non-coding RNAs – novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer

lncRNA

Liver metastasis is the primary cause of death for colorectal cancer (CRC) patients. To investigate the prognostic value of long non-coding RNAs (lncRNAs) on colorectal liver metastases, quantitative reverse-transcriptase PCR (quantitative RT-PCR) was performed on 15 lncRNAs in 51 stage IV CRC with liver metastases and 57 stage I/II CRC specimens. The expression levels of four lncRNAs (GAS5, H19, MEG3 ...

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Long noncoding RNA GAPLINC promotes invasion in colorectal cancer

lncRNA

This study aimed to investigate the role of long noncoding RNAs (lncRNAs) in the metastasis of colorectal cancer (CRC). Metastasis is an important prognostic factor of CRC, and lncRNAs have been implicated in tumor proliferation and metastasis. Genome-wide lncRNA expression patterns in metastatic lymph nodes compared with paired normal lymph nodes of CRC were assessed by microarray analysis. Gastric adenocarcinoma ...

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A genomic screen for long noncoding RNA genes epigenetically silenced in colorectal cancer

lncRNA

Long noncoding RNAs (lncRNAs) have emerged as key components in multiple cellular processes, although their physiological and pathological functions are not fully understood. To identify cancer-related lncRNAs, researchers at the Sapporo Medical University screened for those that are epigenetically silenced in colorectal cancer (CRC). Through a genome-wide analysis of histone modifications in CRC cells, they found that the transcription start ...

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