Tag Archives: Glioblastoma

Glioblastoma multiforme (GBM) is the most common and aggressive malignant adult primary brain tumor. Despite surgical resection followed by radiotherapy and chemotherapy, the median survival rate is...

The angiogenic function of endothelial cells is regulated by numerous mechanisms but the impact of long noncoding RNAs (lncRNAs) has hardly been studied. Goethe-University researchers set out to identify novel and functionally important endothelial lncRNAs. Epigenetically controlled lncRNAs in human umbilical vein endothelial cells (HUVEC) were searched by exon-array analysis after knockdown of the histone demethylase JARID1B. Molecular mechanisms were ...

We are seeking a Phd Student to contribute to the Télévie project: “Long non-coding RNAs in Glioblastoma” within the NorLux Neuro-Oncology Laboratory of the LIH. The successfull candidate will investigate the function of two long non-coding RNAs and evaluate their potential as therapeutic targets to counteract tumour resistance to therapy. The project will involve a collaboration with the Institute of ...