A critical overview of long non-coding RNA in glioma etiology

With the development of whole genome and transcriptome sequencing technologies, a growing body of long non-coding RNAs (lncRNAs) has been identified and is receiving increasing attention. LncRNAs are non-protein encoding transcripts whose functions are crucial for advancing our comprehensive understanding of biological processes in human health and diseases, specifically glioma. It has been established that lncRNAs are differently expressed in the central nervous system and may play a vital role in glioma. As of June 2016, 20 lncRNAs have been identified that may play a role in glioma pathogenesis. Investigation into the role of lncRNAs in glioma may help to identify potential biomarkers which can improve the diagnosis and treatment of glioma.

Categories of ncRNAs


tRNAs transfer RNAs, snoRNAs small nucleolar RNAs, miRNAs microRNAs, siRNAs small interfering RNAs, snRNAs small nuclear RNA, exRNAs extracellular RNA, piRNAs piwi-interacting RNAs, scaRNAs small cajal body specific RNAs, rRNAs ribosomal RNAs, circRNAs circular RNAs

Gao YF, Wang ZB, Zhu T, Mao CX, Mao XY, Li L, Yin JY, Zhou HH, Liu ZQ. (2016) A critical overview of long non-coding RNA in glioma etiology 2016: an update. Tumour Biol [Epub ahead of print]. [abstract]

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