lncRNA Blog lncRNA Research and Industry News
Scientific Organizers: Leonard Lipovich, Jeannie T. Lee, John L. Rinn and James (Ben) Brown
March 15—20, 2015
Keystone Resort, Keystone, Colorado, USA
Sponsored by Cell Research, Isis Pharmaceuticals, Inc., Regeneron Pharmaceuticals, Inc. and Sarepta Therapeutics
Meeting Summary
It has become clear that metazoan genomes are replete with transcription from non-protein-coding regions, generating many long noncoding RNA (lncRNA) transcripts. Recent progress has enabled genome-wide mapping of lncRNAs and has unraveled unifying themes; lncRNAs function as epigenetic regulators, scaffolds, decoys, and enhancers. While these and other themes have been pursued in several meetings, the field has matured in numerous novel directions; the meeting leverages these to characterize lncRNAs comprehensively across metazoan genomes. The aim is to broaden our horizons with emerging data from humans and model systems, empowered by novel genomic technologies, including RNA-protein interaction mapping (CLIP- and RIP-seq), reverse genetics for lncRNAs not conserved in evolution (RNA sequencing in control and lncRNA-perturbed backgrounds), and proteogenomics to empirically bound the translational output of putative lncRNAomes. These topics have recently amassed diverse insights into RNA biology. The meeting should integrate novel findings, enhance previously proposed models of lncRNA function and generate new testable hypotheses. Synthesis of RNA structure, function, evolution and informatics will foster progress in this rapidly growing field. (read more…)
