Tag Archives: Yale University

Postdoc position available – The mechanistic function and molecular structure of long noncoding RNAs

lncRNA

In the Pyle laboratory at Yale University (www.pylelab.org), we use a combination of cell biology and structural biology techniques to explore the architectural features and functions of large noncoding RNA molecules that control RNA splicing, transcription, pathogenicity, and gene expression. We are looking for highly motivated postdoctoral candidates to conduct pioneering work on the structural and functional characterization of long ...

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Post-doc Position Available – lncRNA and Cancer Biology

lncRNA

A postdoctoral position is available in the laboratory of Dr. Nadya Dimitrova, Assistant Professor in the Department of Molecular, Cellular and Developmental Biology at Yale University. Research in the Dimitrova laboratory focuses on investigating the roles of a novel class of genes, called long noncoding RNAs (lncRNAs) in cancer biology. To date, lncRNAs have remained largely uncharacterized but emerging evidence ...

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Visualizing the secondary and tertiary architectural domains of lncRNA RepA

lncRNA

Long noncoding RNAs (lncRNAs) are important for gene expression, but little is known about their structures. RepA is a 1.6-kb mouse lncRNA comprising the same sequence as the 5′ region of Xist, including A and F repeats. It has been proposed to facilitate the initiation and spread of X-chromosome inactivation, although its exact role is poorly understood. To gain insight ...

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Inverted repeat Alu elements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function

LincRNA-p21 is a long intergenic non-coding RNA (lincRNA) involved in the p53-mediated stress response. Yale University researchers sequenced the human lincRNA-p21 (hLincRNA-p21) and found that it has a single exon that includes inverted repeat Alu elements (IRAlus). Sense and antisense Alu elements fold independently of one another into a secondary structure that is conserved in lincRNA-p21 among primates. Moreover, the ...

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