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Eukaryotic genomes generate a heterogeneous ensemble of mRNAs and long noncoding RNAs (lncRNAs). LncRNAs and mRNAs are both transcribed by Pol II and acquire 5′ caps and poly(A) tails, but only mRNAs are translated into proteins. To address how these classes are distinguished, researchers at the Wellcome Trust Centre for Cell Biology, UK identified the transcriptome-wide targets of 13 RNA ...
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