Tag Archives: Washington University School of Medicine

Postdoc position available – discovery and characterization of novel long non-coding RNAs

lncRNA

Position Summary: A postdoctoral scholar position in the area of Computational Biology/Bioinformatics is available in the laboratory of Dr. Christopher Maher at The McDonnell Genome Institute at Washington University School of Medicine in St. Louis. Our lab focuses on developing computational methods for analyzing large-scale cancer genomics data collections from solid tumors to improve our understanding of cancer biology and ...

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Urb-RIP – An Adaptable and Efficient Approach for Immunoprecipitation of lncRNAs and Associated RNAs/Proteins

Post-transcriptional regulation of gene expression is an important process that is mediated by interactions between mRNAs and RNA binding proteins (RBP), non-coding RNAs (ncRNA) or ribonucleoproteins (RNP). Key to the study of post-transcriptional regulation of mRNAs and the function of ncRNAs such as long non-coding RNAs (lncRNAs) is an understanding of what factors are interacting with these transcripts. While several ...

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lncRNA prostate cancer associated transcript-14 (PCAT-14) is prognostic for metastatic disease and survival

lncRNA

Long noncoding RNAs (lncRNAs) are an emerging class of relatively underexplored oncogenic molecules with biological and clinical significance. Current inadequacies for stratifying patients with aggressive disease presents a strong rationale to systematically identify lncRNAs as clinical predictors in localized prostate cancer. To identify RNA biomarkers associated with aggressive prostate cancer researchers from the Washington University School of Medicine obtained radical ...

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Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs

lncRNA

The role of noncoding RNAs in mammalian biology is of great interest, especially since the Encyclopedia of DNA Elements results were published. Many have studied microRNAs in the heart, but little is known about their larger cousins, long noncoding RNAs (lncRNAs). Here, researchers from the Washington University School of Medicine used genome-wide sequencing and improved bioinformatics to quantify lncRNA expression ...

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Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs

lncRNA

The role of noncoding RNAs in mammalian biology is of great interest, especially since the Encyclopedia of DNA Elements results were published. Many have studied microRNAs in the heart, but little is known about their larger cousins, long noncoding RNAs (lncRNAs). Here, researchers from the Washington University School of Medicine used genome-wide sequencing and improved bioinformatics to quantify lncRNA expression ...

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