Tag Archives: Vascular Smooth Muscle

Using RNA-sequencing, researchers from the University of Glasgow identified >300 lncRNAs whose expression was altered in human saphenous vein (HSV) VSMCs following stimulation with IL1α and PDGF. They focused on a novel lncRNA (Ensembl: RP11-94A24.1) which they termed smooth muscle induced lncRNA enhances replication (SMILR). Following stimulation, SMILR expression was increased in both the nucleus and cytoplasm, and was detected ...

Misregulation of angiotensin II (Ang II) actions can lead to atherosclerosis and hypertension. Evaluating transcriptomic responses to Ang II in vascular smooth muscle cells (VSMCs) is important to understand the gene networks regulated by Ang II which might uncover previously unidentified mechanisms and new therapeutic targets. Researchers at the Beckman Research Institute of the City of Hope set out to ...