Tag Archives: urothelial carcinoma-associated 1

Exosomes mediated transfer of lncRNA UCA1 results in increased tamoxifen resistance in breast cancer cells

lncRNA

In this study, researchers at the People’s Hospital of Shouguang compared the loading of urothelial carcinoma-associated 1 (UCA1) in exosomes between tamoxifen sensitive and tamoxifen resistant breast cancer cells and further investigated the role of exosomal transfer of UCA1 in the development of tamoxifen resistance in estrogen receptor (ER) positive breast cancer cells. The researchers isolated exosomes from the culture ...

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Long non-coding RNA UCA1 promotes breast tumor growth

lncRNA

Functional genomics studies have led to the discovery of a large amount of non-coding RNAs from the human genome; among them are long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs could have a critical role in the regulation of cellular processes such as cell growth and apoptosis as well as cancer progression and metastasis. As master gene regulators, lncRNAs ...

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