Tag Archives: University of Queensland

HOTAIR is a novel biomarker of response to endocrine therapy for estrogen receptor positive breast cancer patients

lncrna

Predicting response to endocrine therapy and survival in estrogen receptor positive breast cancer is a significant clinical challenge and novel prognostic biomarkers are needed. Long-range regulators of gene expression are emerging as promising biomarkers and therapeutic targets for human diseases, so researchers at the University of Queensland have explored the potential of distal enhancer elements of non-coding RNAs in the ...

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Dynamic and widespread lncRNA expression in the sponge and the origin of animal complexity

lncRNA

Long non-coding RNAs (lncRNAs) are important developmental regulators in bilaterian animals. A correlation has been claimed between the lncRNA repertoire expansion and morphological complexity in vertebrate evolution. However, this claim has not been tested by examining morphologically simple animals. Here, researchers from the University of Queensland undertake a systematic investigation of lncRNAs in the demosponge Amphimedon queenslandica, a morphologically-simple, early-branching ...

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Featured long non-coding RNA – Gomafu

Gomafu

Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning. Although defective alternative splicing has been linked to SZ, the molecular mechanisms responsible are unknown. Additionally, there is limited understanding of the early transcriptomic responses to neuronal activation. Here, researchers from the University of Queensland, Australia profile these transcriptomic responses and show that long non-coding RNAs (lncRNAs) are dynamically ...

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