Tag Archives: UCA1

Exosomes mediated transfer of lncRNA UCA1 results in increased tamoxifen resistance in breast cancer cells

lncRNA

In this study, researchers at the People’s Hospital of Shouguang compared the loading of urothelial carcinoma-associated 1 (UCA1) in exosomes between tamoxifen sensitive and tamoxifen resistant breast cancer cells and further investigated the role of exosomal transfer of UCA1 in the development of tamoxifen resistance in estrogen receptor (ER) positive breast cancer cells. The researchers isolated exosomes from the culture ...

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Featured Long non-coding RNA – UCA1

Chemotherapy is a reasonable alternative to cystectomy in patients with invasive and advanced bladder cancer. However, bladder cancer cells often develop drug resistance to these therapies and approximately 50% of patients with advanced bladder cancer do not respond to chemotherapy. Recent studies show that long-noncoding RNA (lncRNA) is involved in the development of chemoresistance. Here researchers from the Shanghai Jiaotong ...

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Long non-coding RNA UCA1 promotes breast tumor growth

lncRNA

Functional genomics studies have led to the discovery of a large amount of non-coding RNAs from the human genome; among them are long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs could have a critical role in the regulation of cellular processes such as cell growth and apoptosis as well as cancer progression and metastasis. As master gene regulators, lncRNAs ...

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Featured Long Non-Coding RNA – Urothelial Cancer Associated 1

long non-coding rna

The majority of the human genome is transcribed and generates non-coding RNAs (ncRNAs) that fail to encode protein information. Long non-coding RNAs (lncRNAs) are emerging as a novel class of ncRNAs, but our knowledge about these ncRNAs is limited. Previously, researchers at the Xi’an Jiaotong University, China had identified that a lncRNA, Urothelial cancer associated 1 (UCA1), played an important ...

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