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Despite the inarguable relevance of p53 in cancer, genome-wide studies relating endogenous p53 activity to the expression of lncRNAs in human cells are still missing. Here, by integrating RNA-seq with p53 ChIP-seq analyses of a human cancer cell line under DNA damage, researchers from the Universidad de Navarra, Spain define a high-confidence set of 18 lncRNAs that are p53 transcriptional ...
Read More »Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature
