Tag Archives: TUG1

Long noncoding RNA networks of suppression


Of the approximately 10,000 long noncoding (lnc) RNAs encoded in the human genome, the functions of only a few have been characterized. Mounting evidence suggests that long noncoding RNAs (lncRNAs) can function as microRNA sponges and compete for microRNA binding to protein-coding transcripts. However, the prevalence, functional significance and targets of lncRNA-mediated sponge regulation of cancer are mostly unknown. Here, ...

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Investigation of Circulating LncRNAs in B-cell Neoplasms

Long non-coding RNAs (lncRNA) which are longer than 200 base pairs in length, play important role in the cellular machinery. Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are neoplasms of B-cells. Researchers at Istanbul University aimed to investigate circulating lncRNA levels of CLL and MM patients. For this purpose they selected 5 candidate lncRNAs (TUG1, LincRNA-p21, MALAT1, HOTAIR, and ...

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Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes

Long noncoding RNAs (lncRNAs) form an abundant class of transcripts, but the function of the majority of them remains elusive. While it has been shown that some lncRNAs are bound by ribosomes, it has also been convincingly demonstrated that these transcripts do not code for proteins. To obtain a comprehensive understanding of the extent to which lncRNAs bind ribosomes, researchers ...

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