Tag Archives: triplex

RNA-DNA Triplex Formation by Long Noncoding RNAs


Long noncoding RNAs (lncRNAs) play a pivotal role in the regulation of biological processes through various mechanisms that are not fully understood. Proposed mechanisms include regulation based on RNA-protein interactions, as well as RNA-RNA interactions and RNA-DNA interactions. Here, researchers from Kyoto University focus on one possible mechanism that lncRNA might be using to impact biological function, the RNA-DNA triplex ...

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Researchers use a novel bioinformatics tool for identification of the triple helix forming potential of lncRNA HOTAIR

There is a growing perception that long non-coding RNAs (lncRNAs) modulate cellular function. In this study, researchers from RWTH University Medical School analyzed the role of the lncRNA HOTAIR in mesenchymal stem cells (MSCs) with particular focus on senescence-associated changes in gene expression and DNA-methylation (DNAm). HOTAIR binding sites were enriched at genomic regions that become hypermethylated with increasing cell culture ...

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