Tag Archives: transcription

Living in an RNA world

lncrna

The central dogma postulates that genes are first copied into messenger RNAs, which are then decoded into proteins with the help of transfer RNAs and ribosomal RNAs. It has long been known that there is more to the world of RNA...

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How do lncRNAs regulate transcription?

lncRNA

It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. ...

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Local regulation of gene expression by lncRNA promoters, transcription and splicing

lncRNA

Mammalian genomes are pervasively transcribed to produce thousands of long non-coding RNAs (lncRNAs). A few of these lncRNAs have been shown to recruit regulatory complexes through RNA-protein interactions to influence the expression of nearby genes, and it has been suggested that many other lncRNAs can also act as local regulators. Such local functions could explain the observation that lncRNA expression ...

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Post-doc Position Available – Biochemistry of Plant Non-coding Transcription

lncRNA

Department of Plant and Environmental Sciences Faculty of Science University of Copenhagen Copenhagen Plant Science Centre (CPSC) at the Department of Plant and Environmental Sciences wishes to appoint a highly motivated postdoc in the field of Biochemistry of Plant Non-coding Transcription, commencing on 1 January 2017 or as soon as possible thereafter. The position is a part-time position for 2 ...

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Deciphering the function of non-coding RNAs in prostate cancer

lncRNA

The advent of next-generation sequencing methods is fuelling the discovery of multiple non-coding RNA transcripts with direct implication in cell biology and homeostasis. This new layer of biological regulation seems to be of particular importance in human pathogenesis, including cancer. The aberrant expression of ncRNAs is a feature of prostate cancer, as they promote tumor-suppressive or oncogenic activities, controlling multicellular ...

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“Cat’s Cradling” the 3D Genome by the Act of LncRNA Transcription

lncRNA

There is growing evidence that transcription and nuclear organization are tightly linked. Yet, whether transcription of thousands of long noncoding RNAs (lncRNAs) could play a role in this packaging process remains elusive. Although some lncRNAs have been found to have clear roles in nuclear architecture (e.g., FIRRE, NEAT1, XIST, and others), the vast majority remain poorly understood. In this Perspective, ...

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Unexpected functions of lncRNAs in gene regulation

Long non-coding RNAs (lncRNAs) are a group of molecules that function in gene regulation in yeast, plants and mammals. The precise mechanisms of action for lncRNAs, however, remain largely unclear. The GAL gene cluster has been used as a model system to study the function of these molecules in Saccharomyces cerevisiae, with a historical focus on lncRNA-dependent repression. Strikingly, in ...

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