Tag Archives: Stanford University School of Medicine

Neat1 is a p53-inducible lincRNA essential for transformation suppression

lncrna

The p53 gene is mutated in over half of all cancers, reflecting its critical role as a tumor suppressor. Although p53 is a transcriptional activator that induces myriad target genes, those p53-inducible genes most critical for tumor suppression remain elusive. Here, researchers at Stanford University School of Medicine leveraged p53 ChIP-seq (chromatin immunoprecipitation [ChIP] combined with high-throughput sequencing) and RNA-seq ...

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An inducible long noncoding RNA amplifies DNA damage signaling

lncRNA

Long noncoding RNAs (lncRNAs) are prevalent genes with frequently precise regulation but mostly unknown functions. Here researchers from Stanford University School of Medicine demonstrate that lncRNAs guide the organismal DNA damage response. DNA damage activated transcription of the DINO (Damage Induced Noncoding) lncRNA via p53. DINO was required for p53-dependent gene expression, cell cycle arrest and apoptosis in response to ...

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lncRNA DINO essential to DNA damage response

lncRNA

Stanford researchers have found that a tumor suppressor known as p53 is stabilized by a regulatory lncRNA molecule called DINO. The interaction helps a cell respond to DNA damage and may play a role in cancer development and premature aging. p53-mediated induction of DINO in turn stabilizes p53 through RNA–protein interaction, amplifying DNA damage response. Knowing when to hold them, ...

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Pseudogene lncRNAs are functional regulators of inflammatory signaling

lncRNA

Pseudogenes are thought to be inactive gene sequences, but recent evidence of extensive pseudogene transcription raised the question of potential function. Here researchers at the Stanford University School of Medicine discover and characterize the sets of mouse lncRNAs induced by inflammatory signaling via TNFα. TNFα regulates hundreds of lncRNAs, including 54 pseudogene lncRNAs, several of which show exquisitely selective expression ...

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The first large survey of lncRNA expression within a panel of solid cancers

Breast Cancer

Molecular characterization of tumors has been critical for identifying important genes in cancer biology and for improving tumor classification and diagnosis. Long non-coding RNAs (lncRNAs), as a new, relatively unstudied class of transcripts, provide a rich opportunity to identify both functional drivers and cancer-type specific biomarkers. However despite the potential importance of lncRNAs to the cancer field, no comprehensive survey ...

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