Tag Archives: SNPs

lncRNASNP2 – an updated database of functional SNPs and mutations in human and mouse lncRNAs

lncRNA

Long non-coding RNAs (lncRNAs) are emerging as important regulators in different biological processes through various ways. Because the related data, especially mutations in cancers, increased sharply, the developers at Huazhong University of Science and Technology updated their lncRNASNP to version 2. lncRNASNP2 provides comprehensive information of SNPs and mutations in lncRNAs, as well as their impacts on lncRNA structure and function. ...

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LincSNP 2.0 – an updated database for linking disease-associated SNPs to human long non-coding RNAs

lncrna

Researchers from Harbin Medical University describe LincSNP 2.0, an updated database that is used specifically to store and annotate disease-associated single nucleotide polymorphisms (SNPs) in human long non-coding RNAs (lncRNAs) and their transcription factor binding sites (TFBSs). In LincSNP 2.0, the researchers have updated the database with more data and several new features, including: expanding disease-associated SNPs in human lncRNAs; ...

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Risk-associated SNPs promote prostate cancer through modulating lncRNA expression

Long noncoding RNAs (lncRNAs) represent an attractive class of candidates to mediate cancer risk. Through integrative analysis of the lncRNA transcriptome with genomic data and SNP data from prostate cancer genome-wide association studies (GWAS), researchers at the Princess Margaret Cancer Center identified 45 candidate lncRNAs associated with risk to prostate cancer. They further evaluated the mechanism underlying the top hit, ...

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LncVar – a database of genetic variation associated with long noncoding genes

Long noncoding RNAs (lncRNAs) are essential in many molecular pathways, and are frequently associated with disease, but the mechanisms of most lncRNAs have not yet been characterized. Genetic variations, including SNPs and structural variations, are widely distributed in the genome, including lncRNA gene regions. As the number of studies on lncRNAs grows rapidly, it is necessary to evaluate the effects ...

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Genome-wide interrogation reveals hundreds of long intergenic noncoding RNAs that associate with cardiometabolic traits

lncRNA

Long intergenic noncoding RNAs (lincRNAs) play important roles in disease, but the vast majority of these transcripts remain uncharacterized. A team led by researchers from Duke University defined a set of 54,944 human lincRNAs by drawing on four publicly available lincRNA datasets, and annotated ~2.5 million single-nucleotide polymorphisms from each of 15 cardiometabolic genome-wide association study datasets into these lincRNAs. ...

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