Tag Archives: rna

Living in an RNA world

lncrna

The central dogma postulates that genes are first copied into messenger RNAs, which are then decoded into proteins with the help of transfer RNAs and ribosomal RNAs. It has long been known that there is more to the world of RNA...

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The lncRNA AK144841 could contribute to molecular cascades leading to tumor development

lncRNA

Keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Although some of the early events involved in this pathology have been identified, the subsequent steps leading to tumor development are poorly defined. Researchers from Universite Cote d Azur demonstrate here that the development of mouse tumors induced by the concomitant application of a carcinogen and a ...

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Genomics 2.0: The Importance of RNA Biology

from the Rochester Democrat and Chronicle by Stephen Dewhurst – The ability to sequence the human genome has transformed the way we approach science and medicine.  But understanding our DNA is really only the first step in the Genomics revolution. The same DNA is present in each and every cell of our bodies – yet each of those cells is ...

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Long Noncoding RNAs in Cardiovascular Diseases

lncRNA

In recent years, increasing evidence suggests that noncoding RNAs play important roles in the regulation of tissue homeostasis and pathophysiological conditions. Besides small noncoding RNAs (eg, microRNAs), >200-nucleotide long transcripts, namely long noncoding RNAs (lncRNAs), can interfere with gene expressions and signaling pathways at various stages. In the cardiovascular system, studies have detected and characterized the expression of lncRNAs under ...

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Community Curated Database For LncRNA

lncRNA

A wiki-style database hopes to serve as an online encyclopedia of lncRNA by and for the scientific community. Scientists have set up a long non-coding RNA (lncRNA) database aimed at harnessing the collective knowledge of the scientific community. This study has been published in Nucleic Acids Research. LncRNAs are RNAs that do not code for proteins but are nonetheless actively ...

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Boston area is leading RNA renaissance

Science is leaping forward, and investors are watching closely from the Boston Globe By  Robert Weisman After several years of waning enthusiasm for an approach to drug-making that was once called revolutionary, interest in RNA medicines is suddenly on the upswing, and Boston area start-ups are at the front of the resurgence. The field got a high-octane boost last week ...

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Perspectives on the mechanism of transcriptional regulation by long non-coding RNAs

Long non-coding RNAs (lncRNAs) are increasingly being recognized as epigenetic regulators of gene transcription. The diversity and complexity of lncRNA genes means that they exert their regulatory effects by a variety of mechanisms. Although there is still much to be learned about the mechanism of lncRNA function, general principles are starting to emerge. In particular, the application of high throughput ...

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RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts

lncRNA

The increased application of transcriptome-wide profiling approaches has led to an explosion in the number of documented long non-coding RNAs (lncRNAs). While these new and enigmatic players in the complex transcriptional milieu are encoded by a significant proportion of the genome, their functions are mostly unknown. Early discoveries support a paradigm in which lncRNAs regulate transcription via chromatin modulation, but ...

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RNA: The genome's rising stars

RNA

from Nature by Amy Maxmen When Saba Valadkhan lingered in the hallways at conferences, absorbed in discussions about the strands of ‘junk’ DNA that litter the human genome, she was not looking for work. She was consumed with curiosity about the possibility that long RNA sequences that do not encode proteins nevertheless have a function — enhancing or suppressing gene ...

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