Tag Archives: RNA world

Regulatory non-coding RNAs: revolutionizing the RNA world

The majority of the genomic DNA sequence in mammalian and other higher organisms can be transcribed into abundant functional RNA transcripts, especially regulatory non-coding RNAs (ncRNAs) that are expressed in a developmentally and species-specific regulated manner. Here, the authors review various regulatory non-coding RNAs, including regulatory small non-coding RNAs (sncRNAs) and long non-coding RNAs (lncRNAs), and summarize two and eight ...

Read More »

Long noncoding RNAs mean more than HOTAIR

From Genetic Engineering News by Patricia Fitzpatrick Dimond, Ph.D. Long noncoding RNA (lncRNAs) can regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels. Over the past 10 years, scientists say new methods, including deep sequencing and DNA tiling arrays, have enabled the identification and characterization of the human transcriptome. These techniques completely changed our understanding of genome organization and content ...

Read More »

Emerging Trends of Long Non-coding RNAs in Gene Activation

lncRNA

RNA world has gained increasing importance in the recent past as its role beyond coding for proteins and components of translational machinery is becoming more and more prominent. Recent studies have shown pervasive transcription throughout the genome generating large number of non-coding RNAs (ncRNAs) but few of these RNAs have been shown to perform regulatory functions. Among these regulatory RNAs, ...

Read More »