Tag Archives: Renal Cell Carcinoma

Novel lincRNA SLINKY is a prognostic biomarker in kidney cancer

lncRNA

Clear cell renal cell carcinomas (ccRCC) show a broad range of clinical behavior, and prognostic biomarkers are needed to stratify patients for appropriate management. Stanford University researchers  sought to determine whether long intergenic non-coding RNAs (lincRNAs) might predict patient survival. Candidate prognostic lincRNAs were identified by mining The Cancer Genome Atlas (TCGA) transcriptome (RNA-seq) data on 466 ccRCC cases (randomized ...

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Long noncoding RNAs in kidney and cardiovascular diseases

lncRNA

Transcription of a large part of the human genome results in RNA transcripts that have limited or no protein-coding potential. These include long noncoding RNAs (lncRNAs), which are defined as being ≥200 nucleotides long. Unlike microRNAs, which have been extensively studied, little is known about the functional role of lncRNAs. However, studies over the past 5 years have shown that ...

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AR promotes RCC via lncRNA interaction

lncRNA

The androgen receptor (AR) regulates progression of renal cell carcinoma (RCC) via a mechanism dependent on VHL status and hypoxia, according to data published in Oncogene. RCC is associated with inactivation of the von Hippel–Lindau (VHL) suppressor protein, which targets hypoxia-inducible factors HIF-1α and HIF-2α. VHL inactivation is associated with a good prognosis, but the mechanisms of this effect are ...

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Expression Pattern of Long Non-Coding RNAs in Renal Cell Carcinoma Revealed by Microarray

Recent large-scale transcriptome analyses have found large numbers of transcripts, including that of long non-coding RNAs (lncRNAs), which are aberrant in various diseases, especially cancers. However, it is not clear whether lncRNAs are involved specifically in renal cell carcinoma (RCC). Researchers at the First Affiliated Hospital of Nanjing Medical University investigated the expression patterns of lncRNAs in five RCC tumor ...

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Long Non-coding RNA GAS5 Functions as a Tumor Suppressor in Renal Cell Carcinoma

Renal cell carcinoma (RCC) is a malignancy with a poor prognosis. Researchers at the Medical College of Soochow University, China  aimed to explore whether the expression of Long Non-Coding RNA (LncRNA) growth arrest-specific transcript 5 (GAS5) is associated with RCC genesis. They selected twelve clinical samples diagnosed for renal clear cell carcinoma and found that the LncRNA GAS5 transcript levels ...

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