Tag Archives: regulation

LncRNA – a versatile regulator of the NF-κB signaling circuit

lncRNA

The Nuclear Factor-κB (NF-κB) family of transcription factors play an essential role for the regulation of inflammatory responses, immune function and malignant transformation. Aberrant activity of this signaling pathway may lead to inflammation, autoimmune diseases and oncogenesis. Over the last two decades great progress has been made in the understanding of NF-κB activation and how the response is counteracted for ...

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Local regulation of gene expression by lncRNA promoters, transcription and splicing

lncRNA

Mammalian genomes are pervasively transcribed to produce thousands of long non-coding RNAs (lncRNAs). A few of these lncRNAs have been shown to recruit regulatory complexes through RNA-protein interactions to influence the expression of nearby genes, and it has been suggested that many other lncRNAs can also act as local regulators. Such local functions could explain the observation that lncRNA expression ...

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Role of Long non-coding RNAs in Epigenetic Regulation

The main function of lncRNA in regulation is to control expression of defined genes. For their role in development, they modulate chromatin structure recruiting epigenetic modification proteins to defined sites of the genome. Examples of this function are HOTAIR, Xist and Kcnqot1. HOTAIR is involved in limb formation and cancer meanwhile Kcnqot1 is involved with the imprinting of its loci…

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Role of Long non-coding RNAs in Epigenetic Regulation

The main function of lncRNA in regulation is to control expression of defined genes. For their role in development, they modulate chromatin structure recruiting epigenetic modification proteins to defined sites of the genome. Examples of this function are HOTAIR, Xist and Kcnqot1. HOTAIR is involved in limb formation and cancer meanwhile Kcnqot1 is involved with the imprinting of its loci.

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Long non-coding RNA-guided regulation in organisms

It is clear that RNA is more than just a messenger between gene and protein. The mammalian genome is pervasively transcribed, giving rise to tens of thousands of non-coding transcripts. Whether all of these transcripts are functional remains to be elucidated, but it is evident that there are many functional long non-coding RNAs (lncRNAs). Recent studies have set out to ...

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Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation

Although intergenic long noncoding RNAs (lincRNAs) have been linked to gene regulation in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here researchers at the National Institutes of Health identified 1,524 lincRNA clusters in 42 T cell samples, from early T cell progenitors to terminally differentiated helper T cell subsets. Their analysis revealed highly dynamic ...

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