Tag Archives: R-loop stabilization

Differential stabilization of R-loops – a new mechanism for regulation of gene expression


Roles for long noncoding RNAs (lncRNAs) in gene expression are emerging, but regulation of the lncRNA itself is poorly understood. Now researchers at the John Innes Centre, UK have identified a homeodomain protein, AtNDX, that regulates COOLAIR, a set of antisense transcripts originating from the 3′ end of Arabidopsis FLOWERING LOCUS C (FLC). AtNDX associates with single-stranded DNA rather than ...

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