PTEN is a tumor-suppressor gene that has been shown to be under the regulatory control of a PTEN pseudogene expressed noncoding RNA, PTENpg1. Here, researchers at the Karolinska Institutet, Sweden characterize a previously unidentified PTENpg1-encoded antisense RNA (asRNA), which regulates PTEN transcription and PTEN mRNA stability. They found two PTENpg1 asRNA isoforms, α and β. The α isoform functions in trans, ...
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