Tag Archives: PRC2

The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy

lncRNA

Epigenetic reprogramming is a critical process of pathological gene induction during cardiac hypertrophy and remodeling, but the underlying regulatory mechanisms remain to be elucidated. Here a team led by researchers at UCLA identified a heart-enriched long noncoding (lnc)RNA, named cardiac-hypertrophy-associated epigenetic regulator (Chaer), which is necessary for the development of cardiac hypertrophy. Mechanistically, Chaer directly interacts with the catalytic subunit ...

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RaNA awarded first patent for blocking the interaction of long non-coding RNA with chromatin modifiers

lncRNA

CAMBRIDGE, Mass.–(BUSINESS WIRE)–RaNA Therapeutics, a leader in the discovery and development of a new class of medicines that target RNA, today announced that the United States Patent and Trademark office has issued the first patent covering RaNA’s transcriptional activation platform, U.S. Patent No. 9,328,346, titled “Polycomb-Associated Non-Coding RNAs.” This patent relates broadly to blocking the interaction of long non-coding RNA ...

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Long noncoding RNA-mediated intrachromosomal interactions

Kcnq1ot1 is a long noncoding ribonucleic acid (RNA; lncRNA) that participates in the regulation of genes within the Kcnq1 imprinting domain. Using a novel RNA-guided chromatin conformation capture method, a team led by researchers at the First Affiliated Hospital, Jilin University, China demonstrate that the 5′ region of Kcnq1ot1 RNA orchestrates a long-range intrachromosomal loop between KvDMR1 and the Kcnq1 ...

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