Tag Archives: plasma

Circulating lncRNAs Serve as Diagnostic Markers for Hepatocellular Carcinoma

lncRNA

Circulating (serous or plasmic) long non-coding RNA (lncRNA) as biomarkers for predicting the diagnosis or prognosis of human disease have been well documented. Due to the sensibility or specificity limitation of Alpha Fetoprotein (AFP), a cluster lncRNAs were revealed as fingerprints for hepatocellular carcinoma (HCC). In this study, researchers at Huai’an First People’s Hospital enrolled all the reported circulating lncRNAs ...

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Circulating lncRNA levels too low to serve as biomarkers

lncRNA

Long non-coding RNAs (lncRNA) are a new class of regulatory molecules with diverse cellular functions. Recent reports have suggested that extracellular lncRNAs are detectable in human plasma and may serve as biomarkers. Here, researchers at the Ottawa Hospital Research Institute sought to investigate circulating lncRNAs as potential biomarkers for pulmonary arterial hypertension (PAH). Eighty-four lncRNAs, representing some of the most ...

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The Circulating Long Non-Coding RNA LIPCAR Predicts Survival in Heart Failure Patients

lncRNA

Long non-coding RNAs (lncRNAs) represent a novel class of molecules regulating gene expression. LncRNAs are present in body fluids, but their potential as biomarkers was never investigated in cardiovascular disease. A team led by researchers at the Hannover Medical School performed global transcriptomic analyses in plasma RNA from patients with/without left ventricular (LV)-remodeling after myocardial infarction. Regulated candidates were validated ...

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Circulating Long Non-coding RNAs in Plasma of Patients with Gastric Cancer

lncRNA

Researchers at the Kyoto Prefectural University of Medicine, Japan examined the levels of long non-coding RNAs (lncRNAs) in the plasma of patients with gastric cancer to assess their clinical significance for diseases diagnosing and monitoring. They investigated the stability of plasma lncRNAs, and then confirmed the appropriateness of the lncRNA assay with a pre-amplification method. The levels of plasma lncRNAs, ...

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