Tag Archives: PI3K

LINC00520 plays a functional role in breast cancer

lncRNA

Long non-coding RNAs (lncRNAs) have been implicated in normal cellular homeostasis as well as pathophysiological conditions, including cancer. Harvard Medical School researchers performed global gene expression profiling of mammary epithelial cells transformed by oncogenic v-Src, and identified a large subset of uncharacterized lncRNAs potentially involved in breast cancer development. Specifically, their analysis revealed a novel lncRNA, LINC00520 that is upregulated ...

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Featured long non-coding RNA – CRNDE

lncrna

Colorectal neoplasia differentially expressed (CRNDE) is a novel gene that is activated early in colorectal cancer but whose regulation and functions are unknown. CRNDE transcripts are recognized as long noncoding RNAs (lncRNAs), which potentially interact with chromatin-modifying complexes to regulate gene expression via epigenetic changes. Complex alternative splicing results in numerous transcripts from this gene, and researchers at CSIRO, Australia ...

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