Tag Archives: PCAT-1

Featured long non-coding RNA – PCAT-1


Impairment of double-stranded DNA break (DSB) repair is essential to many cancers. However, although mutations in DSB repair proteins are common in hereditary cancers, mechanisms of impaired DSB repair in sporadic cancers remain incompletely understood. Here, a team led by researchers at the Michigan Center for Translational Pathology describes the first role for a long noncoding RNA (lncRNA) in DSB ...

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Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer

Long noncoding RNAs (lncRNA) are emerging as key molecules in human cancer. Prostate cancer–associated ncRNA transcripts 1 (PCAT-1), a lncRNA, has been recently revealed involving in human prostate cancer progression. However, whether PCAT-1 could serve as novel biomarker to predict prognosis in colorectal cancer (CRC) or not is unknown. In this study researchers from Sun Yat-Sen University, China explored the ...

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