Tag Archives: oncogenic virus.

Researchers hypothesize that the prostate-specific lncRNA PCA3 has been introduced into the human genome by an ancient virus

Prostate cancer, the most frequent type of cancer in men, is surpassed only by lung cancer in causing cancer-related death. Despite major progress in defining the mutational landscape of this tumor, its etiology remains obscure. The intronic long-noncoding RNA (lncRNA) PCA3 is a specific marker of prostate cancer that acts as a trans-dominant negative oncogene to down-regulate the tumor suppressor ...

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