Tag Archives: non-coding genome

Upcoming Symposium – The Non-Coding Genome


EMBL Heidelberg, Germany 13 – 16 Sep 2017 Topics Non-coding RNAs in prokaryotes miRNAs: biogenesis, function and mechanisms siRNAs and piRNAs Transcriptional silencing and dosage compensation Gene silencing in plants Long non-coding RNAs Why attend? In the 50 years since RNA was identified as a central component in the flow of genetic information, it has become increasingly clear that RNA performs ...

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Functional annotation of noncoding variants and prioritization of cancer-associated lncRNAs in lung cancer


Multiple computational tools have been widely applied to the detection of coding driver mutations in cancer; however, the prioritization of pathogenic non-coding variants remains a difficult and demanding task. The present study was performed to distinguish non-coding disease-causing mutations from neutral ones, and to prioritize potential cancer-associated long non-coding RNAs (lncRNAs) with a logistic regression model in lung cancer. A ...

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