Tag Archives: next generation sequencing

NONCODEV5 – a comprehensive annotation database for long non-coding RNAs

lncRNA

NONCODE is a systematic database that is dedicated to presenting the most complete collection and annotation of non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs). Since NONCODE 2016 was released two years ago, the amount of novel identified ncRNAs has been enlarged by the reduced cost of next-generation sequencing, which has produced an explosion of newly identified data. The third-generation ...

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Elucidating the role of host long non-coding RNA during viral infection

lncrna

Research over the past decade has clearly shown that long non-coding RNAs (lncRNAs) are functional. Many lncRNAs can be related to immunity and the host response to viral infection, but their specific functions remain largely elusive. The vast majority of lncRNAs are annotated with extremely limited knowledge and tend to be expressed at low levels, making ad hoc experimentation difficult. ...

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Detection and Analysis of Long Noncoding RNAs

lncRNA

Recent genome-wide studies have yielded new insights into the biological function of long noncoding RNAs (lncRNAs), predominantly through analysis of their genomic addresses. These studies have revealed that a large number of lncRNAs map to regulatory elements in eukaryotic genome regions known as promoter and enhancer elements. Here, researchers from the University of Miami Miller School of Medicine review the ...

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Upcoming Workshop – Measurement and analysis of mRNAs and long non-coding RNAs using next generation sequencing (RNA-Seq)

THIS ONE DAY COURSE is designed for scientists and clinicians with little or no experience in next generation sequencing. The course is run by leading experts and aims to provide the experimental and bioinformatics skills to measure and analysis the expression of mRNA and long non-coding RNA using next generation sequencing. We assume that sequencing will be performed by an external ...

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Long noncoding RNAs: fresh perspectives into the RNA world

lncRNA

Large-scale mapping of transcriptomes has revealed significant levels of transcriptional activity within both unannotated and annotated regions of the genome. Interestingly, many of the novel transcripts demonstrate tissue-specific expression and some level of sequence conservation across species, but most have low protein-coding potential. Here, the authors describe progress in identifying and characterizing long noncoding RNAs (lncRNAs) and review how these ...

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Identification of novel transcripts and noncoding RNAs in bovine skin by RNA-Seq

lncRNA

Deep RNA sequencing (RNA-Seq) has opened a new horizon for understanding global gene expression. The functional annotation of non-model mammalian genomes including bovines is still poor compared to that of human and mouse. This particularly applies to tissues without direct significance for milk and meat production, like skin, in spite of its multifunctional relevance for the individual. Here, researchers fromthe  ...

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