Tag Archives: Neurogenesis

Microarray profiling identifies long noncoding RNAs functionally involved in neurogenesis

lncRNA

The denervated hippocampus provides a proper microenvironment for the survival and neuronal differentiation of neural progenitors. While thousands of lncRNAs were identified, only a few lncRNAs that regulate neurogenesis in the hippocampus are reported. Researchers from Nantong University aimed to perform microarray expression profiling to identify long noncoding RNAs (lncRNAs) that might participate in the hippocampal neurogenesis, and investigate the potential ...

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Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease

Comprehensive analysis of the mammalian transcriptome has revealed that long non-coding RNAs (lncRNAs) may make up a large fraction of cellular transcripts. Recent years have seen a surge of studies aimed at functionally characterizing the role of lncRNAs in development and disease. In this review, the authors discuss new findings implicating lncRNAs in controlling development of the central nervous system ...

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Transcriptome sequencing during mouse brain development identifies long non-coding RNAs functionally involved in neurogenic commitment

Transcriptome analysis of somatic stem cells and their progeny is fundamental to identify new factors controlling proliferation versus differentiation during tissue formation. Here, researchers from the Dresden University of Technology, Germany generated a combinatorial, fluorescent reporter mouse line to isolate proliferating neural stem cells, differentiating progenitors and newborn neurons that coexist as intermingled cell populations during brain development. Transcriptome sequencing ...

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Scientists at Genome Institute of Singapore Discover Gene that Controls the Birth of Neurons

By ACN Newswire – August 27, 2013 10:36 PM EDT Discovery of long non-coding RNA’s role in neurogenesis may lead to cures for diseases such as Alzheimer’s disease Singapore, Aug 28, 2013 – (ACN Newswire) – Scientists at A*STAR’s Genome Institute of Singapore (GIS) have discovered an unusual gene that controls the generation of neurons[1]. This important finding, which is ...

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Featured long non-coding RNA – RMST

Long noncoding RNAs (lncRNAs) are abundant in the mammalian transcriptome, and many are specifically expressed in the brain. Researchers from the Genome Institute of Singapore and Harvard University have identified a group of lncRNAs, including rhabdomyosarcoma 2-associated transcript (RMST), which are indispensable for neurogenesis. Here, they provide mechanistic insight into the role of human RMST in modulating neurogenesis. RMST expression ...

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