Tag Archives: neurodevelopment

Studies of individual lncRNAs using multiple experimental approaches can help reveal the richness and complexity of lncRNA function


During both development and adulthood, the human brain expresses many thousands of long noncoding RNAs (lncRNAs), and aberrant lncRNA expression has been associated with a wide range of neurological diseases. Although the biological significance of most lncRNAs remains to be discovered, it is now clear that certain lncRNAs carry out important functions in neurodevelopment, neural cell function, and perhaps even ...

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A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA

Highlights Identification of LncND with a Catarrhine insertion of 16 MREs for miR-143-3p LncND regulates expression of Notch genes by sequestering miR-143-3p High expression of LncND in radial glia cells in human VZ and OSVZ LncND appears to be involved in the expansion of radial glia cells in primates Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved category ...

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