Tag Archives: Neural Stem Cells

The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells

lncRNA

Tumor cells display features that are not found in healthy cells. How they become immortal and how their specific features can be exploited to combat tumorigenesis are key questions in tumor biology. Here researchers from the IMBA Vienna describe the long non-coding RNA cherub that is critically required for the development of brain tumors in Drosophila but is dispensable for ...

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Microarray profiling identifies long noncoding RNAs functionally involved in neurogenesis

lncRNA

The denervated hippocampus provides a proper microenvironment for the survival and neuronal differentiation of neural progenitors. While thousands of lncRNAs were identified, only a few lncRNAs that regulate neurogenesis in the hippocampus are reported. Researchers from Nantong University aimed to perform microarray expression profiling to identify long noncoding RNAs (lncRNAs) that might participate in the hippocampal neurogenesis, and investigate the potential ...

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Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease

Comprehensive analysis of the mammalian transcriptome has revealed that long non-coding RNAs (lncRNAs) may make up a large fraction of cellular transcripts. Recent years have seen a surge of studies aimed at functionally characterizing the role of lncRNAs in development and disease. In this review, the authors discuss new findings implicating lncRNAs in controlling development of the central nervous system ...

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Integration of Genome-wide Approaches Identifies lncRNAs of Adult Neural Stem Cells and Their Progeny In Vivo

Neurogenesis

Long noncoding RNAs (lncRNAs) have been described in cell lines and various whole tissues, but lncRNA analysis of development in vivo is limited. Here, researchers at the University of California, San Francisco comprehensively analyze lncRNA expression for the adult mouse subventricular zone neural stem cell lineage. They utilize complementary genome-wide techniques including RNA-Seq, RNA CaptureSeq, and ChIP-seq to associate specific lncRNAs with ...

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