Tag Archives: Nanjing Medical University

Microarray expression profiling of long non-coding RNAs in epithelial ovarian cancer

lncRNA

Although numerous long non-coding RNAs (lncRNAs) have been identified to be important in human cancer, their potential regulatory roles in epithelial tumorigenesis and tumor progression in ovarian cancer remain unclear. Researchers from Nanjing Medical University set out to investigate lncRNAs that were differentially expressed (DE) in epithelial ovarian cancer and to explore their potential functions. The lncRNA profiles in five pairs ...

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Genome-wide analysis of long noncoding RNA signature in human colorectal cancer

lncRNA

Long noncoding RNAs (lncRNAs) have been widely regarded as crucial regulators in various biological processes involved in carcinogenesis. However, the comprehensive lncRNA expression signature in colorectal cancer remains fully unknown. Researchers at Nanjing Medical University performed a high throughput microarray assay to detect lncRNA expression profile in three paired human colorectal cancer tissues and their adjacent normal tissues. Additional 90 ...

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LncRNAs are involved in the pathogenesis of diabetic retinopathy through the modulation of multiple pathogenetic pathways

lncRNA

Purpose Long non-coding RNAs (lncRNAs) are broadly classified as transcripts longer than 200 nucleotides. LncRNAs-mediated biology has been implicated in a variety of cellular processes and human diseases. Diabetic retinopathy (DR) is one of the leading causes of blindness. However, little is known about their roles in DR. The aim of this study aimed to identify lncRNAs involved in early ...

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An Integrated Analysis Method for miRNA, lncRNA and mRNA Profiles Based on Their Functional and Positional Relationships

lncRNA

ncRNAs have been identified as potential regulatory molecules and have multiple biological roles. Aberrant expression of specific ncRNAs contributes to multiple biological processes and many human diseases. Herein, researchers at the Nanjing Medical University simultaneously profiled miRNA, lncRNA and mRNA in human HepG2 and L02 cells applying high-throughput sequencing and micro-array technologies. Abnormal miRNA, lncRNA and mRNA profiles were assessed ...

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An integrated evolutionary analysis of miRNA–lncRNA in mammals

Increasing evidence suggests that non-coding RNAs have multiple important roles in transcriptional regulation, and also contribute to the expansion of genome complexity. Here, researchers from the Nanjing Medical University, China attempted to perform an integrative analysis of miRNA–lncRNA in mammals to reveal their potential evolutionary relationships in transcriptional regulation network. The lncRNA of H19 gene includes an internal small non-coding ...

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Featured long non-coding RNA – MEG3

Long noncoding RNAs (lncRNAs) have emerged recently as major players in governing fundamental biological processes, and many of which are altered in expression and likely to have a functional role in tumorigenesis. Maternally expressed gene 3 (MEG3) is an imprinted gene located at 14q32 that encodes a lncRNA associated with various human cancers. However, its biological role and clinical significance ...

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Analysis of long non-coding RNA expression profiles in gastric cancer

lncRNA

Researchers from Nanjing Medical University downloaded two publicly available human exon arrays for gastric cancer and data for the corresponding normal tissue from the Gene Expression Omnibus (GEO) and re-annotated the probes of the human exon arrays to discover probes uniquely mapping to lncRNAs at the gene level. LncRNA expression profiles were generated by using robust multi-array average method in ...

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Featured long non-coding RNA – PCGEM1

Prostate cancer (PCa) gene expression marker 1 (PCGEM1), a long noncoding RNA, has drawn increasing attention for its important role in PCa. However, the association between genetic variations in the PCGEM1 gene and risk of PCa has not been investigated yet. Researchers at Nanjing Medical University, China investigated the effect of two tagging single-nucleotide polymorphism (tSNPs; rs6434568 and rs16834898) in ...

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