Tag Archives: miR-135

A Feedforward Regulatory Loop involving Long Noncoding RNA Controls Early Phases of Myogenesis

The muscle-specific long noncoding RNA linc-MD1 was shown to be expressed during early phases of muscle differentiation and to trigger the switch to later stages by acting as a sponge for miR-133 and miR-135. Notably, linc-MD1 is also the host transcript of miR-133b, and their biogenesis is mutually exclusive. Here, researchers at Sapienza University of Rome describe that this alternative ...

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