Tag Archives: methylation

lncRNAs LOC146880 and ENST00000439577 may promote the progression of NSCLC

lncRNA

To identify what long non-coding RNAs (lncRNAs) are involved in non-small cell lung cancer (NSCLC), researchers from the Shanghai Jiao Tong University School of Medicine analyzed microarray data on gene expression and methylation. Gene expression chip and HumanMethylation450BeadChip were used to interrogate genome-wide expression and methylation in tumor samples. Differential expression and methylation were analyzed through comparing tumors with adjacent ...

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Evf2 lncRNA regulates ultraconserved enhancer methylation and the differential transcriptional control of adjacent genes

lncRNA

Several lines of evidence suggest that long non-coding RNA (lncRNA)-dependent mechanisms regulate transcription and CpG DNA methylation. Whereas CpG island methylation has been studied in detail, the significance of enhancer DNA methylation and its relationship with lncRNAs is relatively unexplored. Previous experiments proposed that the ultraconserved lncRNA Evf2 represses transcription through Dlx6 antisense (Dlx6as) transcription and methyl-CpG binding protein (MECP2) ...

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