Tag Archives: MD Anderson Cancer Center

Long Noncoding RNA in Cancer

lncrna

Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the human genome, may hold missing drivers of cancer and have gained attention recently as a potentially crucial...

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Post-doc position available – lncRNAs’ functional roles in the development of breast/pancreatic/lung cancer, and metabolic diseases

lncRNA

Drs. Liuqing Yang and Chunru Lin, from the Department of Molecular & Cellular Oncology at MD Anderson Cancer Center, are interested in the functional role of long non-coding RNAs (lncRNAs) in cancer and genetic disease. We have demonstrated the molecular mechanisms of long non-coding RNAs in a variety of signaling pathways, including those that regulate breast cancer metastasis and metabolic ...

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A cytoplasmic lncRNA correlates with triple-negative breast cancer

lncRNA

Although long non-coding RNAs (lncRNAs) predominately reside in the nucleus and exert their functions in many biological processes, their potential involvement in cytoplasmic signal transduction remains unexplored. Now, researchers from MD Anderson Cancer Center have identified a cytoplasmic lncRNA, LINK-A (long intergenic non-coding RNA for kinase activation), which mediates HB-EGF-triggered, EGFR:GPNMB heterodimer-dependent HIF1α phosphorylation at Tyr 565 and Ser 797 by ...

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Featured lncRNA – PCAT5

lncRNA

Castration-resistant prostate cancer (CRPC) that arise after the failure of androgen blocking therapies cause most of the deaths from prostate cancer (PC), intensifying the need to fully understand CRPC pathophysiology. A team led by researchers at MD Anderson Cancer Center characterized the transcriptomic differences between untreated PC and locally recurrent CRPC and they report the identification of 145 previously unannotated ...

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Pathway Responsible For Breast Cancer Metastasis Identified By MD Anderson Researchers

lncRNA

from Breast Cancer News Scientists at The University of Texas MD Anderson Cancer Center have discovered a signalling pathway responsible for breast cancer metastasis. The study, led by Liuqing Yang, Ph.D., assistant professor of molecular and cellular oncology, was published in this month’s issue of Cell.  Molecules called long non-coding RNAs (lncRNAs) are known because of their role in metastasis and tumor growth. However, until now, the dimensions ...

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