Tag Archives: long noncoding RNA (lncRNA)

Studies of individual lncRNAs using multiple experimental approaches can help reveal the richness and complexity of lncRNA function

lncrna

During both development and adulthood, the human brain expresses many thousands of long noncoding RNAs (lncRNAs), and aberrant lncRNA expression has been associated with a wide range of neurological diseases. Although the biological significance of most lncRNAs remains to be discovered, it is now clear that certain lncRNAs carry out important functions in neurodevelopment, neural cell function, and perhaps even ...

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A Pipeline for Discovery of DNA methylation patterns in long non-coding RNAs

lncRNA

A systematic pipeline is proposed to discover methylation patterns for lncRNAs. Subtype specific and common lncRNAs differ greatly in functions and structures. Methylation modules enhances the accuracy of prediction of cancers. Despite growing evidence demonstrates that the long non-coding ribonucleic acids (lncRNAs) are critical modulators for cancers, the knowledge about the DNA methylation patterns of lncRNAs is quite limited. Researchers ...

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Request for contributions to a special edition on lncRNA

lncRNA

Research Topic – Roles of Long Non-Coding RNAs in Embryonic Development and Cellular Homeostasis Advances in genomics over the past two decades have established that more than two thirds of the eukaryotic genome is pervasively transcribed, while just >2% codes for protein. Intriguingly, the degree of organismal complexity appears proportional to the transcribed non-coding portion of the genome. The majority ...

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Aberrantly expressed lncRNAs may play an important role in the liver metastasis of colorectal cancer

The liver is the most frequent site of metastasis in colorectal cancer (CRC), in which long noncoding RNAs (lncRNAs) may play a crucial role. In this study, researchers from Zhejiang University performed a genome-wide analysis of lncRNA expression to identify novel targets for the further study of liver metastasis in CRC. Samples obtained from CRC patients were analyzed using Arraystar ...

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